LA+ SIMULATION addresses how recent technologies have changed how we understand the nature of nature. From Plato’s Cave to Baudrillard’s “Simulacrum,” simulations were historically understood as counterfeits or facsimiles and were based on the distinction between a model and its copy. Simulations remain central to mediations between reality and its representation; however, the latest forms of simulation—whether genetic manipulation or computer modeling—are not seen as impediments to truth and knowledge but as tools to uncover the complexities of nature. This issue includes a diverse list of contributors who critically investigate the theme through a myriad of lenses including biology, computer sciences, engineering, environmental science, industrial design, philosophy, planning, among other fields. LA+ SIMULATION is guest edited by Karen M’Closkey and Keith VanDerSys.